Fig. 4.

miR-378a-3p inhibited HCC angiogenesis by targeting TRAF1. A-D Cell viability of HCCLM3 and SMMC-7721 cells transfected with mimic NC, miR-378a-3p, or miR-378a-3p plus TRAF1 and anti-miR-NC, anti-miR-378a-3p, or anti-miR-378a-3p plus siTRAF1 detected by CCK-8 and colony formation assays. E-J Migration, invasion and angiogenesis of HCCLM3 and SMMC-7721 cells transfected with mimic NC, miR-378a-3p, or miR-378a-3p plus TRAF1 and anti-miR-NC, anti-miR-378a-3p, or anti-miR-378a-3p plus siTRAF1 detected by wound healing, invasion and tube formation assays. K VEGF protein concentration in the condition medium of HCCLM3 and SMMC-7721 cells transfected with mimic NC, miR-378a-3p, or miR-378a-3p plus TRAF1 and anti-miR-NC, anti-miR-378a-3p, or anti-miR-378a-3p plus siTRAF1, as detected by ELISA. *P < 0.05; **P < 0.01; ***P < 0.001