Table 2.

Univariate and multivariable analyses of OS and DFS in HCC patients

Variable	OS			DFS
	Univariate analysis	Multivariable analysis		Univariate analysis	Multivariable analysis
	P > |z|	P > |z|	HR(95%CI)	P > |z|	P > |z|	HR(95%CI)
miR-378a-3p expression
Low (n = 54) vs. high (n = 54)	< 0.001	0.003	0.414(0.232-0.736)	0.001	0.010	0.454(0.249-0.828)
Gender
Male (n = 75) vs. female (n = 33)	0.944			0.737
Age (years)
≤ 60 (n = 83) vs. > 60 (n = 25)	0.518			0.837
Grade of differentiation
Low (n = 56) vs. middle-high (n = 52)	0.330			0.444
Tumor diameter (cm)
≤ 5 (n = 50) vs. > 5 (n = 58)	0.588			0.294
Liver function (Child-Pugh stage)
A (n = 92) vs. B or C (n = 16)	0.901			0.980
Hepatocirrhosis
Absent (n = 31) vs. present (n = 77)	0.874			0.698
Hepatitis B virus
Absent (n = 43) vs. present (n = 65)	0.189			0.692
Tumor thrombus
Absent (n = 65) vs. present (n = 43)	0.079			0.052
AFP (ng/ml)
≤ 20 (n = 53) vs. > 20 (n = 55)	0.264			0.973
BCLC stage
I (n = 41) vs. II, III, or IV (n = 67)	0.194			0.149
Envelope
Absent (n = 52) vs. present (n = 56)	0.142			0.946
Tumor satellite
Absent (n = 63) vs. present (n = 45)	0.146			0.411
MVD
High (n = 59) vs. Low (n = 49)	< 0.001	0.018	2.048(1.129-3.715)	0.001	0.022	2.036(1.106-3.746)