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. 2021 Nov 9;20:144. doi: 10.1186/s12943-021-01448-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CircUSP7 regulates the miR-934/SHP2 pathway in CD8⁺ T cells. a The putative binding site of miR-934 in the SHP2 sequence was predicted by StarBase v3.0. b Luciferase activity of pGL3-SHP2 in CD8⁺ T cells cotransfected with miR-934. c and d The mRNA and protein levels of SHP2 were measured by qRT-PCR and western blotting, respectively, in CD8⁺ T cells transfected with miR-934 or miR-934 combined with circUSP7. e SHP2 in representative NSCLC patients was analysed by IHC staining. f A positive correlation between circUSP7 and SHP2 mRNA expression was observed in the CD8⁺ T cells from NSCLC patients (R2 = 0.6580; P < 0.0001). g A negative correlation between circUSP7 and miR-934 expression was observed in the CD8+ T cells from NSCLC patients (R2 = 0.2470; P = 0.0052). h A negative correlation between miR-934 and SHP2 mRNA expression was observed in the CD8⁺ T cells from NSCLC patients (R² = 0.2330; P = 0.0069). The data are presented as the mean ± SD; *P < 0.05, **P < 0.01, NS: not significant