Fig. 7.

Upregulation of CircUSP7 induces cytotoxic T lymphocyte exhaustion by interacting with the miR-934/SHP2 axis in NSCLC patients. a CD8 in tissues from representative NSCLC patients was analysed by IHC staining. b CD8⁺ T cells in 126 pairs of NSCLC tissues and matched nontumour tissues, shown as log2 (tumour/nontumour). c A positive correlation between circUSP7 expression and CD8-positive cell number was observed in the NSCLC tissues (R² = 0.1088; P = 0.0002). d A negative correlation between SHP2 expression and CD8-positive cell number was observed in the NSCLC tissues (R² = 0.1594; P < 0.0001). e A positive correlation between circUSP7 and SHP2 mRNA was observed in NSCLC tissues (R² = 0.2183; P < 0.0001). f The expression level of circUSP7 in the plasma exosomes of these patients after anti-PD1 treatment cycles. The data are presented as the mean ± SD; *P < 0.05, **P < 0.01