Fig. 3.

Signaling pathways that regulate p73 activity. a The diagram shows the TAp73ɑ isoform domain structure and known phosphorylation sites and kinases (yellow), ubiquitinylation sites and ubiquitin ligases (purple), acetylation sites (red), and the sumoylation site (violet). The positions of PTM sites correspond to the TAp73ɑ isoform unless indicated otherwise. TAD, transactivation domain; DBD, DNA binding domain; OD, oligomerization domain; SAM, sterile alpha motif; TID, transcription inhibition domain. See text for the literature. b Regulation of transcriptional activation. In red are denoted proteins and signalling that inhibit transcriptional activation of TAp73 [56, 79, 102, 123, 126, 235, 236] and in blue are signalling pathways and proteins that promote TAp73 regulated pro-apoptotic gene expression [42, 237, 238]. c In squamous carcinoma, TNFa induces nuclear translocation of cREL and induces re-localization of TAp73 binding sites from pro-apoptotic to pro-oncogenic [140]