Table 2.

Physicochemical stability of TH-NP stored at different temperatures (4, 25 and 37 °C) measured at 0, 1, 3, 6 and 12 months

	t (months)	Zav (nm)	PI	ZP (mV)	pH
	0	158.8 ± 1.7	0.068 ± 0.027	− 24.7 ± 1.0	4.20
4 °C	1	158.6 ± 1.8	0.108 ± 0.046	− 20.1 ± 0.6	4.07
	3	159.0 ± 2.1	0.101 ± 0.034	− 17.1 ± 0.1	3.90
	6	168.6 ± 1.7	0.152 ± 0.033	− 15.3 ± 0.1	3.68
	12	204.5 ± 1.3	0.231 ± 0.015	− 11.1 ± 0.7	3.61
25 °C	1	162.3 ± 0.4	0.119 ± 0.015	− 19.1 ± 0.1	3.91
	3	182.3 ± 1.4	0.145 ± 0.020	− 10.3 ± 0.2	3.64
37 °C	1	177.4 ± 1.2	0.128 ± 0.012	− 15.3 ± 0.6	3.32
	3	216.4 ± 2.8	0.205 ± 0.001	− 8.56 ± 0.3	2.95