Table 3.
Ex vivo skin permeation parameters
| Healthy skin | Damaged skin | |||
|---|---|---|---|---|
| TH | TH-NP | TH | TH-NP | |
| J (μg/cm2/h) | 12.68 ± 1.73 | 8.03 ± 0.55 a | 26.43 ± 2.13 a b d | 21.03 ± 0.92 a b |
| Kp (cm/h) | 5.07E−03 ± 6.91E−03 | 3.21E−03 ± 2.19E−04 a | 1.06E−02 ± 3.51E−04 a b d | 8.41E−03 ± 3.69E−04 a b |
| Ap (μg/cm2) | 106.43 ± 9.96 | 96.39 ± 12.68 | 272.36 ± 14.02 a b d | 202.58 ± 11.65 a b |
| As (μg/cm2) | 6.19 ± 1.45 | 10.85 ± 1.12 a c | 5.92 ± 0.92 | 10.83 ± 2.13 a c |
| At (μg/cm2) | 112.61 ± 11.41 | 107.24 ± 13.80 | 278.28 ± 14.93 a b d | 213.78 ± 13.78 a b |
| SSD (p < 0.01) | a | b | c | d |
J: flux, Kp: permeability constant, Ap: total amount penetrated, As: total amount retained inside the skin, At: total amount penetrated and retained inside the skin