Table 7. Timing of peak of each final candidate metabolite in the blood for each treatment group.
For LF and TRF groups ZT 0/ 0 hours is the start of the feeding window and the time of lights on for LF, while for DF ZT0 is the start of the fasting window and the time of lights on. LF and DF groups are in 12h:12h light:dark although feeding in the day and night, respectively. TRF are in constant darkness although feed for the same 12h window (0–12 hours) as the LF group (same experimenter time). DF=dark fed wild type mice, LF=light fed wild type mice, TRF=time restricted fed Per1/2-null mice.
| Metabolite | Class | DF (ZT, hours) | LF (ZT, hours) | TRF (hours) |
|---|---|---|---|---|
| C14.1 | Acylcarnitines | 7.12 | 20.85 | 19.13 |
| C16 | Acylcarnitines | 6.83 | 19.97 | 20.44 |
| C18.1 | Acylcarnitines | 6.65 | 19.92 | 20.18 |
| Ala | Amino.acid | 19.17 | 7.99 | 7.38 |
| Asn | Amino.acid | 18.47 | 6.39 | 6.03 |
| Asp | Amino.acid | 17.46 | 20.42 | 18.01 |
| Glu | Amino.acid | 17.59 | 20.08 | 18.38 |
| Ile | Amino.acid | 21.03 | 7.70 | 0.40 |
| Leu | Amino.acid | 20.36 | 6.65 | 2.85 |
| Met | Amino.acid | 19.90 | 6.20 | 5.90 |
| Phe | Amino.acid | 19.78 | 6.99 | 5.91 |
| Pro | Amino.acid | 19.08 | 6.95 | 6.34 |
| Thr | Amino.acid | 20.06 | 7.93 | 6.33 |
| Val | Amino.acid | 20.50 | 7.95 | 5.05 |
| ADMA | Biogenic_amine | 9.74 | 20.85 | 19.43 |
| Carnosine | Biogenic_amine | 16.39 | 20.41 | 19.03 |
| Histamine | Biogenic_amine | 15.27 | 19.06 | 19.21 |
| Met.SO | Biogenic_amine | 19.37 | 8.04 | 6.54 |
| Putrescine | Biogenic_amine | 15.80 | 19.05 | 16.13 |
| SDMA | Biogenic_amine | 9.83 | 20.78 | 20.54 |
| Serotonin | Biogenic_amine | 13.31 | 6.29 | 18.74 |
| Spermidine | Biogenic_amine | 16.54 | 19.78 | 19.13 |
| Taurine | Biogenic_amine | 16.07 | 20.22 | 19.60 |
| lysoPCaC16:1 | Glycerophospholipids | 6.50 | 18.17 | 18.20 |
| lysoPCaC18:1 | Glycerophospholipids | 6.97 | 18.57 | 16.64 |
| lysoPCaC18:2 | Glycerophospholipids | 5.90 | 15.27 | 12.05 |
| PCaaC32:1 | Glycerophospholipids | 1.41 | 16.26 | 18.89 |
| PCaaC32:2 | Glycerophospholipids | 23.87 | 16.15 | 18.57 |
| PCaaC34:4 | Glycerophospholipids | 6.71 | 17.92 | 0.54 |
| PCaaC38:3 | Glycerophospholipids | 7.48 | 19.01 | 22.51 |
| PCaaC38:4 | Glycerophospholipids | 8.18 | 21.07 | 1.18 |
| PCaaC38:5 | Glycerophospholipids | 7.70 | 20.03 | 0.89 |
| PCaaC38:6 | Glycerophospholipids | 6.81 | 20.36 | 23.97 |
| PCaaC40:4 | Glycerophospholipids | 5.80 | 18.63 | 23.57 |
| PCaaC40:5 | Glycerophospholipids | 7.01 | 19.68 | 23.88 |
| PCaeC34:1 | Glycerophospholipids | 23.59 | 16.45 | 18.99 |
| PCaeC34:3 | Glycerophospholipids | 0.48 | 15.22 | 14.65 |
| PCaeC36:2 | Glycerophospholipids | 22.36 | 12.23 | 10.04 |
| PCaeC38:0 | Glycerophospholipids | 7.80 | 19.97 | 0.71 |
| PCaeC38:2 | Glycerophospholipids | 20.45 | 12.78 | 9.58 |
| PCaeC38:3 | Glycerophospholipids | 2.18 | 16.49 | 19.91 |
| PCaeC42:1 | Glycerophospholipids | 8.78 | 20.70 | 2.72 |