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. 2021 Mar 3;2:219–234. doi: 10.1016/j.jvssci.2021.01.002

Table II.

Features of human abdominal aortic aneurysm (AAA) reflected in mouse models

Feature of human AAA Ang II PPE CaCl2 EPPE
Fibrosis x x x X
Fusiform aneurysm growth -
Frequency increased by BAPN		 x x X
Diameter increased by BAPN
Aortic dissection x
Frequency increased by BAPN		 - - -
ILT - (x) - X
Intramural hemorrhage x - - -
Altered hemodynamics x x - X
Imbalanced proteolysis x x x X
Angiogenesis x x x -
Humoral immune response X x - -
Calcification - - x -
Rupture x (early) - - x (late)
only induced by BAPN

x, Has been described; –, not yet described; AngII, angiotensin II; BAPN, ß-aminopropionitrile; ILT, intraluminal thrombus; PPE, periadventitial elastase application.

The specific features of human AAA considered important have been reviewed by others and us before.26, 27, 28 The table shows if these have been reported in the inducible mouse models. Additionally, the effect of BAPN on the specific aneurysm feature is described.