Figure 5.

Dynamic regulatory pattern of transcription factors

(A) Median Spearman correlation of TF-target pairs within each window calculated in the four windows respectively. The whiskers denoted the 25th percentile and 75th percentile values. The significance was evaluated by ANOVA test. (B) Heatmap showing numbers of targets for each dynamic TF normalized by its maximum number of targets. (C) Sankey diagram showing the relationship between networks W1–W4 and 11 regulatory patterns of TFs. TFs corresponding to each regulatory pattern are listed in the right table. (D–G) TF modules identified based on the Simpson index for each window. (Left) Heatmaps showing the Simpson index for TF pairs. (Right) Subnetworks of the corresponding TF modules with nodes colored by expression levels.