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. Author manuscript; available in PMC: 2022 Nov 20.
Published in final edited form as: Neurosci Lett. 2021 Sep 30;765:136273. doi: 10.1016/j.neulet.2021.136273

Figure 2: Fixed-interval timing was not affected by cortical PFF-induced synucleinopathy.

Figure 2:

A) We trained 3-month-old mice to perform a 12-second fixed-interval timing assay, and then injected animals with cortical PFFs. The mice estimated a 12-second interval by making a nosepoke response; the first nosepoke after 12 seconds was rewarded. B-F) We found no consistent differences in fixed-interval timing between control (blue) and PFF (red) animals in time-response histograms (B), or in C) the curvature of time-response histograms, D) the time animals began nosepoking, as measured by the start time from single-trial analysis, E) the coefficient of variation (CV) of start times from single trial analysis averaged over 10 days, or F) the total number of responses. Data from PFF (n=7) and control (n=7) mice, 6 months after injection.