Table 1.

Epidemiologic and clinical contrasts between KD and MIS-C

	KD	MIS-C
Locations of highest global incidence	Japan, East Asia	Western Europe, North America and South America
Racial and ethnic predominance	East Asian heritage	Hispanic and African heritage
Median age and age range	Median 3–4 yearsTypical range <6mo-6yExtended range 2mo-15y	Median 8–9 yearsRange 1yo-19yo
Typical clinical features	Fever; and including 3–5 of the following: Rash, Conjunctivitis, Mucositis, Extremity swelling/rash, lymphadenopathy	Fever, Shock and one of the following: Rash, abdominal pain, neurologic changes, conjunctivitis, lymphadenopathya
Uveitis	Common	Very common and pronouncedb
Shock	Rare but can occur in KD shock syndrome (5–10% of all KD)	At least 25–50% of cases
Seasonality of disease	Evident but not associated with a single infectious agent	Clear association with SARS-CoV-2

KD, Kawasaki disease; MIS-C, Multisystem Inflammatory Syndrome in Children; SARS, Severe acute respiratory syndrome coronavirus -2.

^a25–40% of MIS-C meets KD criteria.

^bSmall case series; evidence limited.