TABLE 1.
Natural polymorphic mutations associated with viral loads in antiviral drug-naive HIV-infected patients
| No. | HIV proteina | Codon no. | Amino acid change | Designationb |
|---|---|---|---|---|
| 1 | RT | 322 | Ser>Thr | RT:S322T |
| 2 | RH | 79 | Asn>Ser | RH:N79S |
| 3 | IN | 17 | Ser>Asn | IN:S17N |
| 4 | IN | 50 | Met>Ile | IN:M50I |
| 5 | Gp120 | 252 | Arg>Lys | G120:R252K |
| 6 | Gp120 | 448 | Asn>Arg | G120:N448R |
| 7 | Gp41 | 24 | Met>Val | G41:M24V |
| 8 | Gp41 | 24 | Met>Leu | G41:M24L |
| 9 | Gp41 | 254 | Leu>Arg | G41:L254R |
| 10 | Gp41 | 340 | Leu>Ala | G41:L340A |
| 11 | Nef | 92 | Lys>Arg | NF:K92R |
| 12 | Nef | 98 | Glu>Asp | NF:E 98D |
| 13 | Nef | 133 | Val>Ile | NF:V133I |
| 14 | Nef | 143 | Tyr>Phe | NF:Y143F |
a
RT, reverse transcriptase; RH, RNase H; IN, integrase; G120, gp120 envelope; G41, gp41 envelope; NF, nef.
b
Name of designated mutation in this study.