Figure 6.

Metabolic clusters of excitatory neurons and their link with Alzheimer's disease

(A) The single-cell transcriptomic dataset was clustered into eight metabolic clusters with distinct patterns of activity for three metabolic tasks.

(B) Percentage of the representation of each metabolic cluster within the ROSMAP dataset (Mathys et al., 2019).

(C) Enrichment analysis (one-tailed Fisher's exact test) within each metabolic cluster of clinic-pathological variables (Mathys et al., 2019) (AD, pathology; stage, stage of the disease; amyloid, overall amyloid level; braaksc, Braak stage; ceradsc, assessment of neuritic plaques; cogdx, clinical consensus diagnosis; apoe, APOE (apolipoprotein E) genotype; sex, sex of the patient).

(D) Percentage of samples of each metabolic cluster from each patient and their associated Alzheimer's diagnosis.

(E–G) Expression patterns of the metabolic tasks (left: percentage of patient samples associated with an active task; right: related median score) presenting a dysregulated activity across groups of patients with different diagnosis for Alzheimer's disease (blue and red represent patients without and with Alzheimer's disease, respectively). The horizontal lines represent the median of the distribution.