Table 6.

Comparison of Different Combinations of Serum CST1 and Three Traditional Tumor Markers for Early Diagnosis of ESCC Patients

Index	AUC	SE	95% CI	Sensitivity (%)	Specificity (%)
CEA, CYFRA21-1	0.669	0.032	0.586–0.712	33.04	92.64
CEA, SCC-Ag	0.730a	0.029	0.672–0.788	29.46	92.25
CEA, CST1	0.660	0.032	0.596–0.724	37.50	91.09
CYFRA21-1, SCC-Ag	0.705	0.031	0.644–0.766	39.29	91.09
CYFRA21-1, CST1	0.659	0.032	0.596–0.722	42.86	90.31
SCC-Ag, CST1	0.730a	0.030	0.673–0.788	43.75	91.09
CEA, CYFRA21-1, SCC-Ag	0.732	0.030	0.674–0.790	40.18	89.53
CEA, CYFRA21-1, CST1	0.668	0.032	0.605–0.732	44.64	88.76
CEA, SCC-Ag, CST1	0.736b	0.039	0.678–0.793	49.11	89.53
CYFRA21-1, SCC-Ag, CST1	0.728	0.030	0.670–0.786	48.21	89.15
CEA, CYFRA21-1, SCC-Ag, CST1	0.735	0.030	0.677–0.793	50.89	87.98

Notes: ^aThe highest AUC in the combined detection of any two indicators. ^bThe highest AUC in the combined detection of any three indicators.