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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Cytokine. 2021 Jul 19;146:155641. doi: 10.1016/j.cyto.2021.155641

Figure 1: Regulation of expression of IL-17C.

Figure 1:

(A) TLR 2, TLR 3, and TLR 5 upregulate the expression of IL-17C at mucosal surfaces [see Table 2 for references]. (B) Expression of IL-17C downstream of TNF-α is mediated by ERK1/2, p38, and NF-κB. In the presence of IL-17A, phosphorylation levels of Akt may play a role in synergy between TNF-α and IL-17A stimulation of the expression of IL-17C. IL-17A is also known to increase the expression of MCPIP, which may sequester IL-17C in the cell, preventing release. IL-1β increases IL-17C expression through NF-κB. Co-treatment with IL-13 reduces IL-1β-mediated IL-17C expression via STAT6. Solid arrows represent activation pathways, whereas dashed arrows represent translocation through the nuclear membrane. Images created using BioRender.com