Table 2 |.

Gene expression upregulated by IL-17C stimulation of human mucosal tissues

	Gene	Stimulant	Read-out	Cell Type	Reference
Antimicrobial Agent	Granzyme-B (GZMB)	Flagellin	IPA analysis	NCM460	[10]
	Human Beta Defensin 2 (hBD2)	TNF-α & IL-17C*	mRNA	keratinocytes	[28]
		IL-17C^		keratinocytes	[7]
		IL-17C	mRNA	NHBE cells	[16]
	Lipocalin-2 (LCN2)	H. pylori	IPA analysis	gastric mucosa	[12]
		TNF-α & IL-17C	mRNA	keratinocytes	[28]
	Peptidase Inhibitor 3 (PI3)	TNF-α & IL-17C	mRNA	keratinocytes	[28]
	S100A7	TNF-α & IL-17C	mRNA	keratinocytes	[28]
	S100A8	TNF-α & IL-17C	mRNA	keratinocytes	[28]
		H. pylori	IPA analysis	gastric mucosa	[12]
	S100A9	TNF-α & IL-17C	mRNA	keratinocytes	[28]
		H. pylori	IPA analysis	gastric mucosa	[12]
	S100A12	IL-17C	mRNA	NHBE cells	[16]
Cytokines and Chemokines	CCL20	TNF-α & IL-17C	mRNA	keratinocytes	[28]
	CSF3	IL-17C	mRNA	NHBE cells	[16]
	CXCL8	H. pylori	IPA analysis	gastric mucosa	[12]
	G-CSF	IL-17C	protein	keratinocytes	[7]
	IFN-γ	H. pylori	IPA analysis	gastric mucosa	[12]
	IL-1 β	TNF-α & IL-17C	mRNA	keratinocytes	[28]
		Flagellin	IPA analysis	NCM460	[10]
		IL-17C.Fc (IgG1) fusion protein	protein	THP-1 cells	[4]
	IL-1F5	TNF-α & IL-17C	mRNA	keratinocytes	[28]
	IL-1F9	TNF-α & IL-17C	mRNA	keratinocytes	[28]
	IL-6	TNF-α & IL-17C	mRNA	keratinocytes	[28]
		IL-17C	mRNA	human dermal microvascular endothelial (hDME) cells	[28]
		H. pylori	IPA analysis	gastric mucosa	[12]
	IL-8	TNF-α & IL-17C	mRNA	keratinocytes	[28]
	IL-17C	TNF-α & IL-17C	mRNA	keratinocytes	[28]
	IL-19	TNF-α & IL-17C	mRNA	keratinocytes	[28]
	IL-23A	H. pylori	IPA analysis	gastric mucosa	[12]
	TNF-α	IL-17C	mRNA	hDME cells	[28]
		TNF-α & IL-17C	mRNA	keratinocytes	[28]
		IL-17C.Fc (IgG1) fusion protein	protein	THP-1 cells	[4]
		H. pylori	IPA analysis	gastric mucosa	[12]
Other	BCL2	H. pylori	IPA analysis	gastric mucosa	[12]

Annotations for Table 2– following page

^*TNF-α (2ng/mL); IL-17A (200ng/mL)

^{^}IL-17C = concentrations ranged from 2ng/mL to 200ng/mL