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. 2021 Oct 14;47:102165. doi: 10.1016/j.redox.2021.102165

Table 2.

SCFA receptors and ligand specificity.

Acetic (C2:00) Propionic (C3:0) Butyric (C4:0) Pentanoic (C5:0)
FFAR3 (GPR41) ++ + ++ ++
FFAR2 (GPR43) ++ ++ ++ +
GPR109A ++
Olfr78 ++ +

Abbreviations: FFAR1: free fatty acid receptor 1; FFAR2: free fatty acid receptor 2; FFAR3: free fatty acid receptor 3; GPR40: G protein-coupled receptor 40; GPR41: G protein-coupled receptor 41; GPR43: G protein-coupled receptor 43; GPR109A: G protein-coupled receptor 109 A; olfr78: olfactory receptor 78. Note + and ++ denote low and high affinity, respectively [5,6].