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. 2021 Oct 10;3(1):vdab144. doi: 10.1093/noajnl/vdab144

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© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Expression of 5-top genes across GBM subtypes and survival. Top panels show the gene expression of the top-5 genes (A) NKAIN1, (B) UBE2E2, (C) F13A1, (D) RNF149, and (E) PLAUR across proneural (PN), classical (CLA), and mesenchymal (MES) subtypes of GBM in Wang et al. (2017) study. Bottom panel shows corresponding survival data of GBM samples with high or low expression of the top 5-genes. Signature similarity profiles of single-cell RNA sequencing from (F) Neftel et al. (2019)¹⁰ dataset and (G) Richards et al. (2021)¹⁸ dataset. HR = log Hazard Ratio. **P < .01, ***P < .001.