Table 2:
Reactome pathways enriched in TPR interactors list (FDR <5E-9)
| Reactome Pathway | Identifier | Protein Number | Fold enrichment | P value | FDR |
|---|---|---|---|---|---|
| Chromatin organization | R-HSA-4839726 | 27 | 20.4 | 9.70E-27 | 1.11E-23 |
| Chromatin modifying enzymes | R-HSA-3247509 | 27 | 20.4 | 9.70E-27 | 2.22E-23 |
| SUMO E3 ligases SUMOylate target proteins | R-HSA-3108232 | 15 | 17.32 | 3.26E-14 | 1.86E-11 |
| SUMOylation | R-HSA-2990846 | 15 | 16.69 | 5.42E-14 | 2.47E-11 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 16 | 14.22 | 7.48E-14 | 2.85E-11 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 9 | 50.99 | 9.89E-13 | 3.23E-10 |
| HCMV Early Events | R-HSA-9609690 | 12 | 21.76 | 1.15E-12 | 3.29E-10 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 9 | 47.99 | 1.58E-12 | 4.00E-10 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 9 | 41.84 | 4.58E-12 | 1.05E-09 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 9 | 40.8 | 5.59E-12 | 1.16E-09 |
| SUMOylation of DNA replication proteins | R-HSA-4615885 | 9 | 37.95 | 9.87E-12 | 1.61E-09 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 15 | 11.43 | 9.06E-12 | 1.72E-09 |
| SUMOylation of RNA binding proteins | R-HSA-4570464 | 9 | 37.95 | 9.87E-12 | 1.73E-09 |
| HCMV Infection | R-HSA-9609646 | 12 | 17.55 | 1.18E-11 | 1.80E-09 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 8 | 50.02 | 2.16E-11 | 2.60E-09 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 8 | 50.02 | 2.16E-11 | 2.75E-09 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 8 | 50.02 | 2.16E-11 | 2.91E-09 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 8 | 50.02 | 2.16E-11 | 3.09E-09 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 8 | 48.35 | 2.73E-11 | 3.12E-09 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 8 | 46.79 | 3.42E-11 | 3.39E-09 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 12 | 16 | 3.23E-11 | 3.51E-09 |
| Nuclear import of Rev protein | R-HSA-180746 | 8 | 46.79 | 3.42E-11 | 3.55E-09 |
| SUMOylation of SUMOylation proteins | R-HSA-4085377 | 8 | 45.33 | 4.25E-11 | 3.89E-09 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 8 | 45.33 | 4.25E-11 | 4.05E-09 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 8 | 43.95 | 5.26E-11 | 4.29E-09 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 8 | 43.95 | 5.26E-11 | 4.45E-09 |
| SUMOylation of chromatin organization proteins | R-HSA-4551638 | 9 | 30.79 | 5.20E-11 | 4.57E-09 |