Table 2.
The positions of 84 base differences between ERR1091908 and FJ882941.1
| ORF | CDS (position in NC_004718.3) | Mutations found in ERR1091908 compared to FJ882941.1 | Function [ref] | |
|---|---|---|---|---|
| Positions of nucleotide change (number) | Positions of amino acid change in SARS-CoV protein (number) | |||
| ORF 1a | 265-13413 | 654,707,1771,1905,2976,3229,3491,3603,3845,4731,4808,5015,5061,5236,5412,6087,6265,6459,6476,7484,8004,8922,10119,10658,12411,13149 (26) | 148,503,989,1076,1194,1489,1515,1584,1658,2001,2071,2407,3465 (13) | Involved in viral replication and transcription, and virus pathogenesis [13], [15] |
| ORF 1ab | 265-21485 | 13874,13925,14178,14630,14876,15497,15605,15740,15821,15905,16356,16386,17269,17602,18238,18239,18244,18245,18749,18860,19082,19814,19917,20528,20555,20789,21038 (27) | 987,997,1291,1402,1614,1616,2174 (7) | |
| S | 21492-25259 | 21860,22206,22352,22423,23243,23374,23468,23518,23823,24249,24873,24910,24957 (13) | 239,311,628,676,778,920,1128,1140,1156 (9) | Associated with cell entry of SARS-CoV and viral transmission [14], [16] |
| ORF 3a | 25268-26092 | 25550,25626,25783,25800,26049 (5) | 120,178,261 (3) | Playing roles in virus uptake and release, viral-related apoptosis, and formation of viral envelope [17] |
| ORF 3b | 25689-26153 | 25783,25800,26049,26121 (4) | 32,38,121,145 (4) | Involving in immunomodulation, and acting as interferon antagonist [17] |
| E | 26117-26347 | 26121,26226,26241,26335 (4) | 2,37,42 (3) | A small integral membrane proteins with roles in virus morphogenesis, assembly, budding, and replication [15] |
| M | 26398-27063 | NA | NA | NA |
| ORF 6 | 27074-27265 | 27167,27248 (2) | 32,59 (2) | Acting as a β-interferon antagonist and contribute to virulence [17] |
| ORF 7a | 27273-27641 | 27290,27639 (2) | 123 (1) | Involving in virus-host interaction and contribute to SARS-CoV pathogenesis [17] |
| ORF 7b | 27638-27772 | 27639,27648 (2) | 1,4 (2) | A potential attenuating factor [17] |
| ORF 8a | 27779-27898 | NA | NA | Potential roles in the host ubiquitin–proteasome system [17] |
| ORF 8b | 27864-28118 | 27917 (1) | NA | |
| N | 28120-29388 | 28557,29271,29324 (3) | 402 (1) | Playing role in virus replication and transcription, and acting as an interferon antagonist [15], [16] |
| ORF 9b | 28130-28426 | NA | NA | Inducing caspase-dependent apoptosis [17] |
| Total number | NA | 84 | 45 | NA |