Fig. 2.

Sequence similarity between HSP65 of Mycobacterium bovis BCG and nucleoprotein (N) of SARS-CoV-2. The pair-wise alignment of HSP65 with nucleoprotein (Cov-2 N) was performed as specified in “Materials and methods.” A All the sequences of Cov-2 N with similarity to HSP65, detected with both T-Coffee (upper line) and Clustal Omega (lower line), are reported below the corresponding sequences of HSP65, as in Fig. 1. Underlined are the sequences of CoV-2 N identified with both methods as similar with HSP65. In red are the amino acid residues common to both proteins. B The same sequences, as in A, are presented in graphical form to visualize the portions of CoV-2 N with similarity to HSP65. In red are the sequences identified experimentally as epitopes of CoV-2 N