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. 2021 Oct 14;134(21):2619–2628. doi: 10.1097/CM9.0000000000001804

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Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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MiR-345-5p regulates lung adenocarcinoma cell apoptosis, migration, and invasion via RhoA. (A) Apoptosis of PC-9 and H1650 cells transfected with the indicated plasmids was explored by flow cytometry analysis. (B, C) The migration and invasion of cells transfected with the indicated plasmids were detected by wound healing and transwell assays. ^∗P < 0.001 vs. NC mimics; ^†P < 0.001 vs. miR-345-5p mimics; ^‡P < 0.01 vs. miR-345-5p mimics; ^§P < 0.01 vs. NC mimics; ^||P < 0.05 vs. miR-345-5p mimics. FITC: Fluorescein isothiocyanate; miR-345-5p: MicroRNA-345-5p; NC: Negative control; PI: Prodium iodide; RhoA: Ras homolog family member A.