Table 1. The comparison of ZBED6 KO and IGF2 KI model in pigs and mice.

		Bama pig		Large white pig[1,3]	mice[10]
genetic modification		ZBED6 KO (pigs in this study)	IGF2 KI[11]	IGF2 mutant	IGF2 KI	ZBED6 KO
general	reproduction	normal	normal	normal	normal	normal
	body weight	-	25% ↑	-	20% ↑	15% ↑
	lean rate	6.6% ↑	NA	4% ↑	NA	NA
	heart weight	17.2% ↑	NA	8% ↑	15% ↑	mild ↑
	liver weight	13.1% ↑	NA	-	-	20–25% ↑
	fat	10.4% ↓(BFT)	mild ↓(BFT)	20% ↓(BFT)	- (GWD)	- (GWD)
	serum IGF2	2-fold ↑	NA	-	8 fold ↑	8 fold ↑
muscle	hypertrophy	GM and myocardium	LD	NA	NA
	fiber area	128% ↑	40% ↑
	triglyceride	50% ↓	NA
IGF2	heart	1.5-fold ↑	NA	1-fold ↑	4 fold ↑		8 fold ↑
	muscle	1.5-fold ↑ (GM)	2-fold ↑	1.2-fold ↑	15 fold ↑ (TA)		20 fold ↑ (TA)
		2.5-fold ↑(LD)
	kidney	2 fold ↑	NA	NA	10 fold ↑		30 fold ↑
	liver	-	NA	-	NA		NA
IGF2 methylated	liver	10%	NA	26%	NA
	muscle	0.50%	1.25%	3.40%

BFT: back fat thickness, GWD: gonadal white adipose, TAW: tibialis anterior weight, GM: gastrocnemius muscle