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. 2021 Oct 10;13(10):e18645. doi: 10.7759/cureus.18645

Figure 1. Comparison of the plasma concentration.

Figure 1

Comparison of the plasma concentration after infusion of curcumin-HSA formulation with 300mg curcumin compared to the same dosage of a formulation dissolved in water. It shows a significantly prolonged plasma presence of free, non-metabolized curcumin in the HSA-bound curcumin formulation compared to the water-dissolved curcumin formulation. The presence of free and thus therapeutically effective curcumin is extended to 210 minutes after infusion in the HSA-bound formulation. The initial plasma concentration after the 120-minute infusion of the HSA formulation shows a five-fold higher amount of curcumin in the blood than with the water-dissolved curcumin variant.