Table 2.
Pathway analysis of DE Genes CSH71(NCI) 250 nm vs. Control.
| Pathway | Source | P‐value | q‐value | Top Hits_overlap |
|---|---|---|---|---|
| Upregulated | ||||
| Olfactory transduction ‐ Homo sapiens (human) | KEGG | 8.47E‐10 | 2.05E‐07 | OR5B21; OR52N1; OR52J3; OR56A3; OR4N5; OR1S1; OR11H1; OR2L2; OR10K2; OR6N1; OR8K3; OR2B3; OR6Y1; OR5W2; OR2L8; OR5A1 |
| HTLV‐I infection ‐ Homo sapiens (human) | KEGG | 0.00072468 | 0.01288891 | JUN; EGR1; ADCY8; ZFP36; TNF; CREM; ATF3 |
| MAPK signaling pathway ‐ Homo sapiens (human) | KEGG | 0.00353542 | 0.03619249 | GADD45A; JUN; TNF; DUSP5; DUSP4; FLNC |
| TNF signaling pathway ‐ Homo sapiens (human) | KEGG | 0.00376954 | 0.03619249 | PTGS2; JAG1; JUN; TNF |
| Inflammatory bowel disease (IBD) ‐ Homo sapiens (human) | KEGG | 0.00631366 | 0.05071297 | STAT4; TNF; JUN |
| Osteoclast differentiation ‐ Homo sapiens (human) | KEGG | 0.00698855 | 0.0527318 | CALCR; TNF; JUN; FOSL2 |
| Leishmaniasis ‐ Homo sapiens (human) | KEGG | 0.00837645 | 0.05637127 | PTGS2; TNF; JUN |
| Downregulated | ||||
| Pathway | source | p‐value | q‐value | Top Hits_overlap |
| Pathogenic Escherichia coli infection ‐ Homo sapiens (human) | KEGG | 3.10E‐05 | 0.00018592 | TUBA3E; TUBA3D; TLR5 |
| Gap junction ‐ Homo sapiens (human) | KEGG | 0.00460401 | 0.01381204 | TUBA3E; TUBA3D |
Microarray RNA analysis and pathway analysis of Hut78 CTCL cells with 100 nM CSH71 at 48 h treatment. Several significantly up‐regulated pathways are in bold, such as the Olfactory transduction pathway, MAPK signaling pathway and TNF pathway. Likewise, down‐regulated pathway, Pathogenic Escherichia coli infection, etc. Two representative signaling molecules TNF and TRL5 are highlighted in bold. p‐values for two most significantly pathways are Olfactory transduction (unregulated, P = 8.47E‐10, bold) and (down‐regulated, Pathogenic Escherichia coli infection, P = 3.10E‐05, bold), respectively.