FIG. 1.

Alignment of the C. elegans (C prefix) prolyl 4-hydroxylase α subunits PHY-1 (GenBank no. Z81134) and PHY-2 (GenBank no. Z69637) to the human (H prefix) α(I) (M24487) and α(II) (U90441) subunits using ClustalW. Gaps (dashes) were introduced for maximal alignment, and signal peptides were removed. Highly conserved cysteine and active-site histidine, aspartic acid, and lysine residues (23) are indicated by an asterisk. The conserved tryptophan₇₆, converted to a stop codon in the phy-1 gene of the dpy-18 (e364) allele, is indicated by a dollar sign.