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. 2022 Feb;192(2):195–207. doi: 10.1016/j.ajpath.2021.10.009

Figure 1.

Figure 1

Body weight change over time and post-mortem lung weights. A: Body weight of control mock-inoculated hamsters (blue) compared with SARS-CoV-2–inoculated hamsters (red). Mock-inoculated animals demonstrated a steady increase typical of young growing animals. In contrast, SARS-CoV-2–inoculated animals had a sharp decline in body weight until 6 days post inoculation (DPI) when body weight began to increase. B: At the time of necropsy, lung weights of SARS-CoV-2–inoculated (red) hamsters had significantly higher total lung weights at both 4 and 7 DPI compared with mock-inoculated animals, consistent with lesion severity and consolidation. ∗∗P < 0.01, ∗∗∗P < 0.001 (unpaired t-test).