Bosek 1996.

Study characteristics
Methods	Randomized controlled trial
Participants	NSAID n = 40, age 55.1 ± 12.9 Type of breast surgery: mastectomy or lumpectomy with axillary lymph node dissection Breast cancer history Placebo n=20, age 56.4 ± 16 Type of breast surgery: mastectomy or lumpectomy with axillary lymph node dissection Breast cancer history
Interventions	NSAID versus placebo Ketorolac 30 mg IV or ketorolac 30 mg via Jackson‐Pratt drain at end of surgery and every 6 hours postoperatively 0.9% NaCL IV or Jackson‐Pratt drain at end of surgery and every 6 hours postoperatively
Outcomes	Postoperative pain intensity 18 hours after surgery: VAS 1.15 ± 1.25 versus 1.1 ± 1.4 Incidence rate or severity of PONV: 16 versus 14 Opioid use at 18 hours after surgery: 1.7 ± 3.1 mg versus 2.7 ± 3.9 mg morphine
Notes	No declaration of funding or conflicts of interest
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided
Incomplete outcome data (attrition bias) All outcomes	Low risk	All randomized participants were analyzed
Selective reporting (reporting bias)	High risk	No information available for trial registrations or protocols to determine if all reported outcomes were assessed