Wen 2015.

Study characteristics
Methods	Randomized controlled trial
Participants	NSAID n = 20, age 45.5 ± 9.1 Type of breast surgery reconstruction mastectomy Breast cancer history Fentanyl alone n = 20, age 43.9 ± 7.8 Type of breast surgery reconstruction: mastectomy Breast cancer history
Interventions	NSAID versus other analgesic Flurbiprofen 3 mg/kg IV infusion 48 hours postoperative
Outcomes	Postoperative pain intensity within 24 (± 12) hours of surgery: VAS 2.6 ± 0.66 versus 2.55 ± 0.66 Incidence rate or severity of PONV: 2 versus 12 participants Opioid use within 24 (± 12) hours of surgery 26.8 ± 1.8 mg versus 80.7 ± 4.8 mg morphine
Notes	No declaration of funding or conflicts of interest
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomized controlled trial
Allocation concealment (selection bias)	Low risk	Secure web‐based computer‐generated randomisation process that automatically records numbers and assignments. A researcher who did not participate in the clinical trial performed the process of randomising patients.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blinded study
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double‐blinded study
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patients completed the study
Selective reporting (reporting bias)	High risk	No information available for trial registrations or protocols to determine if all reported outcomes were assessed

IM: intramuscular
IV: intravenous
NaCl: sodium chloride
NRS: numerical rating scale
NSAID: nonsteroidal anti‐inflammatory drug
PONV: postoperative nausea and vomiting
VAS: visual analog scale