Fig. 2. Treatment algorithm for moderate-to-severe atopic dermatitis. AD: atopic dermatitis, EASI: eczema area and severity index, AZA: azathioprine, MTX: methotrexate, MMF: mycophenolate mofetil. ^*Consider increasing the severity level if the patient has a diurnal or nocturnal pruritus score of ≥7 on a numerical rating scale or a Dermatology Life Quality Index of ≥10. ^†Adjuvant treatments may be considered but remain controversial.