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. 2021 Oct;10(10):3995–4011. doi: 10.21037/tlcr-21-767

Figure 5.

Figure 5

USP5 expression is positively associated with the expression of CCND1 at the protein but not at the mRNA level. (A) Expression levels of USP5 mRNA in lung adenocarcinoma (LUAD) tissues (n=535) and normal lung tissues (n=59) cited from The Cancer Genome Atlas (TGCA) dataset (http://cancergenome.nih.gov/). ***, P<0.001, Student’s t-test. (B,C) Immunohistochemical (IHC) analysis of the protein levels of USP5 in clinical LUAD tissues (n=76) and normal lung tissues (n=87). Representative images (×200) (B) and scores (C) of IHC analysis of USP5 are shown. ***, P<0.001, Student’s t-test. (D) The association of USP5 level with tumor node metastasis (TNM) staging cited in the TCGA dataset. **, P<0.01, Student’s t-test. (E) Expression levels of CCND1 mRNA in LUAD tissues (n=535) and normal lung tissues (n=59) cited from the TCGA dataset. (F,G) IHC analysis of the protein levels of CCND1 in clinical LUAD tissues (n=76) and normal lung tissues (n=87). Representative images (×200) (F) and scores (G) of IHC analysis of CCND1 are shown. ***, P<0.001, Student’s t-test. (H) The clinical association of USP5 protein level with CCND1 protein level in LUAD tissues. **, P<0.01, Kruskal-Wallis test.