Figure 1.

In silico models predict that a single TIP administration would generate multi-fold reductions in SARS-CoV-2

(A) Schematic of the TIP concept with putative mechanism of action for reducing wild-type virus transmission. Sustained therapeutic efficacy (i.e., molecular parasitism) requires efficient conditional propagation with a basic reproduction ratio (R₀) >1.

(B) In silico patient-validated model of SARS-CoV-2 dynamics for upper respiratory tract (URT) and lower respiratory tract (LRT).

(C) Viral-load dynamics in URT and LRT in the presence and absence of a single TIP administration on day 0 showing an R₀ >1 TIP is predicted to substantially lower SARS-CoV-2 in both URT and LRT.

(D) Parameter sensitivity analysis for ρ and ψ showing reduction in peak viral load in LRT across eight orders of magnitude (left) and zoomed region (green box, right); the blue dot represents empirically measured values (see Figures 2C and 4E).

See also Figure S1.