Table 1.
Inhibition of HCV and SARS-CoV-2 replication by selected drugs
(nM) | HCV |
SARS-CoV-2 |
||||
---|---|---|---|---|---|---|
Infection |
Replicon RNA transfection |
|||||
EC50 | CC50 | EC50 | CC50 | EC50 | CC50 | |
Daclatasvir | <0.006 | >25 | <0.006 | >25 | – | – |
PI4KA-G1 | 23.8 | >4,000 | 19.8 | >4,000 | – | – |
PIK-III | 318.2 | >4,000 | 309.5 | >4,000 | 172.5 | ∼50,000 |
Remdesivir | – | – | – | – | 79.2 | >10,000 |