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. 2021 Oct 1;296:567–576. doi: 10.1016/j.jad.2021.09.098

Table 2.

Sub-group analyses for standardized mean change (SMC) in mental health symptoms.

Moderator Test of sub-group difference Sub-groups Effect estimate
Age QM(1) = 0.001, p = .978, I2 = 97.9% Adults (n = 127) SMC = .105 [95% CI: .033 to .178], z = 2.84, p = .005, I2 = 98.0%
Child/adolescents (n = 38) SMC = .114 [95% CI: -.030 to .257], z = 1.56, p = .120, I2 = 94.6%%
Gender QM(1) = 2.73, p = .098, I2 = 93.8% Males (n = 13) SMC = .086 [95% CI: -.030 to .202], z = .145, p = .147, I2 = 89.9%
Females (n = 14) SMC = .150 [95% CI: .005 to .295], z = 2.02, p =  .043, I2 = 95.0%
Continent QM(3) = 0.916, p =  .822, I2 = 97.9% Europe (n = 100) SMC = .093 [95% CI: .002 to .185], z = 2.00, p =  .046, I2 = 97.8%
North America (n = 45) SMC = .132 [95% CI: -.012 to .277], z = 1.79, p =  .073, I2 = 98.5%
Other (n = 15) SMC = .160 [95% CI: .085 to .234], z = 4.20, p < .001, I2 = 87.3%
Mix (n = 5) SMC = .052 [95% CI: -.081 to .184], z = 0.76, p =  .446, I2 = 72.1%
Population QM(3) = 8.735, p =  .033, I2 = 97.8% General population (n = 75) SMC = .118 [95% CI: .042 to .193], z = 3.04, p =  .002, I2 = 97.9%
University student (n = 40) SMC = .133 [95% CI: -.005 to .272], z = 1.87, p =  p =  .059, I2 = 95.2%
Pre-existing mental health condition (n = 25) SMC = -.017 [95% CI: -.211 to .178], z = 0.17, = .867, I2 = 97.7%
Pre-existing physical health condition (n = 14) SMC = .249 [95% CI: .067 to .431], z = 2.68, p =  .007, I2 = 97.9%
Publication status QM(1) = 0.053, p = .818, I2 = 97.9% Journal article (n = 122) SMC = .101 [95% CI: .021 to .181], z = 2.48, p =  .013, I2 = 98.1%
Pre-print (n = n = 43) SMC = .121 [95% CI: .001 to .241], z = 1.97, p =  .049, I2 = 96.5%
Representative sampling QM(1) = 0.114, p =  .735, I2 = 97.9% Reported (n = 34) SMC = .125 [95% CI: .043 to .206], z = 3.01, p =  p =  .003, I2 = 98.1%
Not reported or unclear (n = 131) SMC = .101 [95% CI: .020 to .181], z = 2.43, p =  .015, I2 = 96.2%
Sample size QM(1) = 0.047, p =  .829, I2 = 97.9% ≥1000 (n = n = 24) SMC = .108 [95% CI: .013 to .203], z = 2.32, p = .013, I2 = 98.9%
<1000 (n = 141) SMC = .108 [95% CI: .031 to .184], z = 2.77, p =  .006, I2 = 94.6%
Pre-pandemic measurea QM(1) = 0.167, p =  .683, I2 = 97.9% More than 12 months prior to pandemic measure (n = 42) SMC = .092 [95% CI: -.008 to .193], z = 1.80, p =  p =  .072, I2 = 98.3%
12 months or less prior to pandemic measure (n = 119) SMC = .117 [95% CI: .032 to .203], z = 2.70, p =  .007, I2 = 97.3%
Mode of survey QM(1) = 5.056, p =  .025, I2 = 97.9% Consistent between pre and during pandemic (n = 82) SMC = .179 [95% CI: .098 to .260], z = 4.31, p < .001, I2 = 98.1%
Inconsistent or unclear (n = 83) SMC = .034 [95% CI: -.064 to .132], z = 0.685, p = .493, I2 = 95.9%
Conflicts of interest QM(1) = 0.111, p =  .739, I2 = 97.9% Statement included + no reported conflicts (n = 124) SMC = .112 [95% CI: .041 to .184], z = 3.07, p =.001, I2 = 97.6%
No conflict statement or reported conflicts (n = 41) SMC = .089 [95% CI: -.065 to .243], z = 1.32, p = .257, I2 = 98.1%
Attritionb QM(1) = 0.045, p =  p =  .832, I2 = 97.8% Level of attrition ≤25% (n = 47) SMC = .038 [95% CI: -.055 to .131], z = 0.80, p = .424, I2 = 98.5%
Level of attrition > 25% (n = 66) SMC = .103 [95% CI: -.002 to .208], z = .1.93, p =  .054, I2 = 95.4%
a

Number of comparisons does not add up to n = 165 because for a small number of effects it was unclear whether the pre-pandemic measures was collected more than 12 months prior to the post-pandemic outbreak measure.

b

We also examined whether attrition was associated with the change in mental health symptoms pre-post pandemic using meta-regression. There was no significant association (coefficient = .092 [95% CI: -.185 to .370] z = .653, p =  .514).