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. 2021 Nov 10;102:108348. doi: 10.1016/j.intimp.2021.108348

Fig. 7.

Fig. 7

DP1 receptor is activated during the resolution phase in the rat ARDS model. (A).SD rats were administered with LPS (3 mg/kg) or the same volume of sterile intravenously, BW245C (DP1 receptor agonist 5 mg/kg), 15(R)-15-methyl-PGD2(CRTH2/DP2 receptor agonist 5 mg/kg), MK-0524(DP1 receptor antagonist 5 mg/kg) and CAY-10471(CRTH2/DP2 receptor antagonist 5 mg/kg) were injected to rats i.p. at 12 h after LPS exposure. Lung tissues were collected at 24 h. (B) Representative micrographs of pulmonary histology, as shown by H&E staining. (C) Acute lung injury score. (D–F) The mRNA levels of IL-1β, IL-6, TNF-α were measured via qPCR. Data are shown as mean ± SEM, n = 6. *p < 0.05, **p < 0.01,***p ＜ 0.001,****p < 0.0001.