Table 4.
Pearson correlation and p values for relevant post-chemotherapy echo, cardiac MRI, and serum biomarkers as well as cumulative anthracycline dose
| Cumulative anthracycline dose |
NT-pro-BNP |
|||
|---|---|---|---|---|
| R value | P value | R value | P value | |
| LVIDd Z-score | 0.009 | 0.964 | −0.185 | 0.346 |
|
| ||||
| LVEF (%) | −0.186 | 0.343 | 0.283 | 0.137 |
|
| ||||
| LVSF (%) | −0.286 | 0.292 | 0.093 | 0.633 |
|
| ||||
| MV E/A | −0.453 | 0.016* | −0.045 | 0.818 |
|
| ||||
| Lateral E/E′ | −0.010 | 0.960 | −0.121 | 0.866 |
|
| ||||
| ALS | −0.07 | 0.723 | −0.376 | 0.045* |
|
| ||||
| ACS | 0.032 | 0.886 | −0.077 | 0.728 |
|
| ||||
| MRI LVEDV/m2 | −0.007 | 0.973 | −0.156 | 0.419 |
|
| ||||
| MRI LVEF (%) | 0.166 | 0.4 | 0.283 | 0.254 |
|
| ||||
| MRI ECV 4 chamber | 0.403 | 0.046* | 0.608 | 0.001* |
|
| ||||
| MRI ECV short axis | 0.484 | 0.011* | 0.607 | 0.001* |
|
| ||||
| NT-pro-BNP | 0.362 | 0.05* | – | – |
|
| ||||
| ST2 | −0.015 | 0.94 | −0.09 | 0.643 |
*
p<0.05.
ACS, average circumferential strain; ALS, average longitudinal strain; ECV, extracellular volume; LVEDV, left ventricular end diastolic volume; LVEF, left ventricular ejection fraction; LVIDd, left ventricular internal diameter in diastole; LVSF, left ventricular shortening fraction; NT-pro-BNP, N-terminal brain natriuretic peptide; ST2, interleukin 1 receptor-like 1 protein.