Table 1.
Participant demographics for each of the tract analysis and network analysis groups. Perinatal clinical information, as well as scores from neonatal MRI assessment of basal ganglia and thalami (BGT), white matter (WM) and posterior limbs of the internal capsule (PLIC), are given for cases. P-values are shown for case-control comparison of age, index of multiple deprivation, and MABC-2 scores using Wilcoxon rank sum tests, and for case-control comparison of sex, and MABC-2 scores < 15th centile using Fisher’s exact test. *P < 0.05. aEEG = amplitude integrated electroencephalogram; MABC-2 = Movement Assessment Battery for Children, Second Edition; TH = therapeutic hypothermia.
| Tract Analysis | Network Analysis | |||||
|---|---|---|---|---|---|---|
| Case (n = 33) | Control (n = 36) | p | Case (n = 22) | Control (n = 32) | p | |
| Age, median (range) | 6.9 (6.0–7.9) | 7.0 (6.1–7.9) | 0.5555 | 7.0 (6.0–7.8) | 7.0 (6.1–7.8) | 0.5428 |
| Sex, male/female | 18/15 | 19/17 | 0.8894 | 12/10 | 16/16 | 0.7526 |
| Index of Multiple Deprivation, median (range) | 7 (1–10) | 7 (2–10) | 0.5211 | 7 (1–10) | 7 (2–10) | 0.8174 |
| MABC-2 Assessment: | ||||||
| MABC-2 total score, median (range) | 9 (3–19) | 11 (5–18) | 0.0866 | 10 (3–19) | 11 (5–18) | 0.3955 |
| MABC-2 total score < 15th centile, n (%) | 12 (36) | 2 (6) | 0.0021* | 9 (41) | 2 (6) | 0.0041* |
| Aiming & catching score, median (range) | 9 (2–15) | 9 (5–18) | 0.5090 | 10 (4–15) | 9 (5–18) | 0.6967 |
| Aiming & catching score < 15th centile, n (%) | 6 (18) | 2 (6) | 0.1401 | 4 (18) | 2 (6) | 0.2111 |
| Balance score, median (range) | 9 (3–19) | 11 (5–15) | 0.0782 | 10 (4–19) | 11.5 (5–15) | 0.4187 |
| Balance score < 15th centile, n (%) | 7 (21) | 3 (8) | 0.1767 | 3 (14) | 2 (6) | 0.3875 |
| Manual dexterity score, median (range) | 9 (1–18) | 11 (3–18) | 0.0773 | 9 (1–18) | 11 (3–18) | 0.2620 |
| Manual dexterity score < 15th centile, n (%) | 11 (33) | 4 (11) | 0.0397* | 7 (32) | 4 (13) | 0.0996 |
| Neonatal MRI Assessment: | ||||||
| BGT, median (range) | 0 (0–2) | – | – | 0 (0–1) | – | – |
| WM, median (range) | 1 (0–3) | – | – | 1 (0–3) | – | – |
| PLIC, median (range) | 0 (0–2) | – | – | 0 (0–1) | – | – |
| Perinatal Clinical Information: | ||||||
| Mode of delivery, vaginal/instrumental/emergency caesarean in labour/emergency caesarean not in labour | 11/8/10/4 | – | – | 8/6/7/1 | – | – |
| Assisted ventilation at 10 min of age, yes/no | 24/9 | – | – | 17/5 | – | – |
| Cardiac compressions required, yes/no | 13/20 | – | – | 8/14 | – | – |
| Apgar score at 10 min of age, median (range) | 6 (0–10) | – | – | 5 (0–10) | – | – |
| Worst pH within 1 h of birth, median (range) | 6.98 (6.70–7.25) | – | – | 6.98 (6.77–7.25) | – | – |
| Worst base excess within 1 h of birth, median (range) | −16.0 (-31.0 to −4.8) | – | – | −16.1 (-31.0 to −4.8) | – | – |
| Grade of encephalopathy: moderate, n (%) | 25 (76) | – | – | 18 (82) | – | – |
| Grade of encephalopathy: severe, n (%) | 8 (24) | – | – | 4 (18) | – | – |
| aEEG abnormalities prior to TH: moderate, n (%) | 30 (91) | – | – | 20 (91) | – | – |
| aEEG abnormalities prior to TH: severe, n (%) | 3 (9) | – | – | 2 (9) | – | – |