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. 2021 Nov 3;32:102873. doi: 10.1016/j.nicl.2021.102873

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Correlation analysis among CNR_LC, network attributes, and MoCA score in PD group. (A) CNR_LC was significantly correlated with MoCA score in the PD group. (B) CNR_LC was significantly correlated with the network attributes of cognitive- and motor-related regions in the PD group. (C) Network attributes of two cognitive-related regions were associated with MoCA score in the PD group. (D) Mediation analysis showed that reduced NE of the STG was a mediator between LC degeneration and cognitive decline. CNR_LC: Contrast-to-noise ratio of the locus coeruleus; MoCA: Montreal Cognitive Assessment; PD: Parkinson’s disease; DC: Degree centrality; NE: Nodal efficiency; STG: Superior temporal gyrus; INS: Insular gyrus; IPL: Inferior parietal lobule; Cun: Cuneus; PrG: Precentral gyrus.