Table 3.

Comparison of automated segmentations to manual tracing.

Wave	Technique	Structure volume (mean cm${}^3$ ±SD)		Comparison of techniques to manual tracing
				%Volume difference ±SD		%Volume overlap ±SD		%False positive ±SD		%False negative ±SD		Correlation
		Left	Right	Left	Right	Left	Right	Left	Right	Left	Right	Left	Right
Wave 1	Manual	1.46 ± 0.18	1.45 ± 0.18
	volBrain	0.90 ± 0.12***	0.92 ± 0.13***	38.18 ± 7.60	36.48 ± 7.59	68.16 ± 4.92	68.21 ± 4.86	10.28 ± 5.17	11.65 ± 5.95	44.73 ± 5.73	44.13 ± 5.65	0.61***	0.62***
	CS-FS	1.65 ± 0.21***	1.66 ± 0.25***	16.96 ± 11.50	18.78 ± 13.99	78.32 ± 3.65	78.78 ± 3.33	26.76 ± 5.61	26.69 ± 6.13	15.36 ± 5.06	14.22 ± 4.81	0.62***	0.59***
	LG-FS	1.72 ± 0.22***	1.78 ± 0.26***	22.85 ± 13.16	28.08 ± 15.79	74.88 ± 3.84	75.97 ± 3.41	31.56 ± 5.66	31.79 ± 5.98	16.80 ± 5.19	13.60 ± 4.40	0.61***	0.57***
	FSL	1.50 ± 0.30	1.48 ± 0.33	19.59 ± 13.43	20.95 ± 14.46	79.19 ± 4.94	77.05 ± 7.07	20.49 ± 8.89	22.45 ± 8.38	19.02 ± 11.21	21.03 ± 13.63	0.09	0.08
Wave 2	Manual	1.48 ± 0.17	1.48 ± 0.18
	volBrain	0.92 ± 0.11***	0.93 ± 0.12***	37.89 ± 6.53	37.25 ± 7.01	67.78 ± 4.06	68.23 ± 4.67	11.17 ± 4.81	11.05 ± 5.27	44.99 ± 4.81	44.38 ± 5.41	0.63***	0.61***
	CS-FS	1.65 ± 0.22***	1.63 ± 0.23***	15.93 ± 10.67	13.94 ± 10.62	77.69 ± 3.46	79.11 ± 3.38	26.78 ± 4.95	24.75 ± 5.40	16.71 ± 6.09	15.89 ± 5.34	0.54***	0.66***
	LG-FS	1.74 ± 0.22***	1.77 ± 0.23***	21.64 ± 13.17	23.88 ± 12.31	75.40 ± 3.26	76.78 ± 3.34	30.83 ± 5.13	30.18 ± 4.89	16.59 ± 5.33	14.24 ± 5.00	0.53***	0.64***
	FSL	1.55 ± 0.32*	1.52 ± 0.30	20.48 ± 16.28	18.21 ± 12.87	79.03 ± 5.20	77.28 ± 5.97	21.24 ± 9.15	22.58 ± 7.91	18.48 ± 11.20	20.96 ± 11.92	−0.03	0.14
Wave 3	Manual	1.49 ± 0.21	1.51 ± 0.21
	volBrain	0.92 ± 0.15***	0.94 ± 0.16***	38.44 ± 7.71	37.89 ± 8.09	67.54 ± 4.87	67.34 ± 5.33	10.81 ± 5.13	11.59 ± 5.13	45.32 ± 5.79	45.27 ± 6.34	0.67***	0.70***
	CS-FS	1.63 ± 0.23***	1.68 ± 0.25***	14.35 ± 10.85	16.04 ± 13.23	76.90 ± 4.88	77.25 ± 4.15	26.91 ± 5.70	27.06 ± 6.44	18.32 ± 7.21	17.24 ± 5.45	0.66***	0.59***
	LG-FS	1.72 ± 0.24***	1.80 ± 0.26***	20.71 ± 13.60	26.29 ± 21.86	74.52 ± 4.28	74.78 ± 8.19	31.25 ± 5.37	32.03 ± 8.29	18.05 ± 6.87	16.22 ± 9.39	0.61***	0.59***
	FSL	1.58 ± 0.33*	1.52 ± 0.30	21.50 ± 17.89	17.79 ± 13.33	79.52 ± 4.26	77.68 ± 4.71	21.42 ± 9.59	21.21 ± 7.50	17.65 ± 10.81	21.37 ± 11.35	−0.05	0.15

Note: Means, standard deviations, and the statistical significance of the two paired sample t-test between manual and automated segmentations as well as summary of automated segmentation performance, mean percentage of volume difference, percentage of volume overlap, percentage of false positive and Pearson’s correlations between automated and manual segmentations. *p$<$ 0.05; **p$<$ 0.01; ***p$<$ 0.001.