Table 2.
Histological characteristics of the 152 patients with liver biopsy and of the 97 patients with all valid tests available.
| Variables | Liver biopsy (n = 152) | All valid tests available (n = 97) |
NASH (n = 30) |
No NASH (n = 67) |
p value |
|---|---|---|---|---|---|
| Fragment length (mm) | 13.6 ± 6.3 | 14.3 ± 6.4 | 16.4 ± 6.0 | 13.4 ± 6.4 | 3.0×10-2 |
| Number of portal tracts | 13.6 ± 8.0 | 14.1 ± 7.9 | 17.2 ± 7.7 | 12.7 ± 7.6 | 1.1×10-2 |
| Steatosis grade, n (%) | 7.3×10-8 | ||||
| 0 (<5%) | 40 (26) | 23 (24) | 0 (0) | 23 (34) | |
| 1 (5-33%) | 37 (24) | 21 (22) | 0 (0) | 21 (31) | |
| 2 (34-66%) | 40 (26) | 25 (26) | 14 (47) | 11 (16) | |
| 3 (>66%) | 35 (24) | 28 (28) | 16 (53) | 12 (19) | |
| Lobular inflammation, n (%) | 4.9×10-19 | ||||
| 0 | 98 (64) | 60 (62) | 0 (0) | 60 (90) | |
| 1 | 46 (30) | 31 (32) | 26 (87) | 5 (7) | |
| 2-3 | 8 (5) | 6 (6) | 4 (13) | 2 (3) | |
| Ballooning grade, n (%) | 1.1×10-15 | ||||
| 0 | 87 (57) | 54 (56) | 0 (0) | 54 (81) | |
| 1 | 59 (39) | 39 (40) | 26 (87) | 13 (20) | |
| 2 | 6 (4) | 4 (4) | 4 (13) | 0 (0) | |
| NAS score, n (%) | 7.8×10-17 | ||||
| <3 | 79 (52) | 45 (46) | 0 (0) | 45 (67) | |
| 3-4 | 46 (30) | 34 (35) | 12 (40) | 22 (33) | |
| ≥5 | 27 (18) | 18 (19) | 18 (60) | 0 (0) | |
| Fibrosis stage, n (%) | 9.1×10-11 | ||||
| F0 | 75 (49) | 47 (48) | 1 (3) | 46 (69) | |
| F1 | 63 (42) | 38 (39) | 19 (63) | 19 (28) | |
| F2 | 11 (7) | 10 (10) | 8 (27) | 2 (3) | |
| F3 | 3 (2) | 2 (2) | 2 (7) | 0 (0) | |
| F4 | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
p values are those of the t tests between NASH and no NASH groups for each variable.
NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH, non-alcoholic steatohepatitis.