Table 4.
Diagnostic performance of MRI-PDFF for grading steatosis and diagnosing NASH (n = 128).
| AUROC (95% CI) | Cut-off | Se (95% CI) | Sp (95% CI) | PPV (95% CI) | NPV (95% CI) | |
|---|---|---|---|---|---|---|
| S0 vs. S1-3 (>5%) | 0.97 (0.94–1.00) | 6% | 0.95 (0.88–0.98) | 0.84 (0.66–0.95) | 0.95 (0.88–0.98) | 0.84 (0.66–0.95) |
| S0-1 vs. S2-3 (>33%) | 0.95 (0.91–0.98) | 11% | 0.95 (0.87–0.99) | 0.80 (0.68–0.89) | 0.82 (0.72–0.90) | 0.94 (0.85–0.99) |
| S0-2 vs. S3 (>66%) | 0.92 (0.87–0.97) | 20% | 0.83 (0.65–0.94) | 0.84 (0.75–0.90) | 0.61 (0.45–0.76) | 0.94 (0.87–0.98) |
| NASH | 0.84 (0.77–0.91) | 12% | 0.97 (0.86–1.00) | 0.60 (0.50–0.71) | 0.50 (0.38–0.62) | 0.98 (0.90–1.00) |
Values are provided with their 95% CI.
AUROC, area under the receiver operating characteristic curve; MRI-PDFF, MRI-proton density fat fraction; NASH, non-alcoholic steatohepatitis; NPV, negative predictive value; PPV positive predictive value; Se, sensitivity; Sp, specificity.