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Changes in major clinical parameters between the pretreatment period and the on-treatment period: (A) systolic blood pressure (SBP), (B) left ventricular mass index (LVMI), and (C) plasma B-type natriuretic peptide (BNP) concentrations. The boxes show the interquartile range, with the median value indicated by the horizontal line; whiskers show the range. P values were determined using the Mann-Whitney U test.
