Table 1.
Baseline characteristics of patients, stratified by initial loss of consciousness
| Characteristica | LOC present (n = 352) | LOC absent (n = 2372) | p value |
|---|---|---|---|
| Age, mean (SD), y | 60 (15) | 62 (14) | 0.005 |
| Female | 171 (49) | 958 (40) | 0.04 |
| Race | 0.3 | ||
| White | 215 (61) | 1539 (65) | |
| Black | 137 (39) | 829 (35) | |
| Modified Rankin before ICH | 0 (0–1) | 0 (0–1) | 0.5 |
| Medical history | |||
| Diabetes | 103 (29) | 663 (28) | 0.3 |
| Hypertension | 281 (80) | 1917 (81) | 0.8 |
| Elevated cholesterol | 90 (26) | 760 (32) | 0.07 |
| CAD | 34 (10) | 318 (13) | 0.1 |
| AF | 25 (7) | 230 (10) | 0.2 |
| TIA | 10 (3) | 115 (5) | 0.1 |
| CHF | 22 (6) | 175 (7) | 0.6 |
| Home medications | |||
| Aspirin | 57 (16) | 651 (27) | < 0.001 |
| Non-aspirin antiplatelet | 20 (6) | 135 (6) | 1.0 |
| Warfarin | 26 (7) | 216 (9) | 0.3 |
| Statin | 74 (21) | 592 (25) | 0.1 |
| Clinical | |||
| Glucose value by EMS | 146 (116–198) | 125 (106–154) | < 0.001 |
| ED Glasgow Coma Score | 6 (3–9) | 15 (13–15) | < 0.001 |
| ED SBP | 200 (167–226) | 184 (158–213) | < 0.001 |
| Laboratory testing in emergency department | |||
| Serum glucose | 158 (130–201) | 127 (106–163) | < 0.001 |
| Hemoglobin | 13.6 (12.2–15.1) | 13.8 (12.6–15.0) | 0.2 |
| Platelet count | 231 (182–272) | 219 (177–266) | 0.06 |
| PTT | 27 (25–30) | 29 (26–32) | < 0.001 |
| First INR | 1.0 (0.98–1.10) | 1.0 (1.0–1.1) | 0.7 |
| CT characteristics | |||
| Lobar hemorrhage location | 87 (25) | 731 (31) | 0.02 |
| Initial CT ICH volume | 26 (10–58) | 10 (4–24) | < 0.001 |
| Peak ICH volume | 28 (12–64) | 11 (4–27) | < 0.001 |
| ICH expansion (> 33%) | 36 (16) | 275 (17) | 0.7 |
| IVH on any CT scan | 271 (77) | 978 (41) | < 0.001 |
| Peak IVH volume | 8 (0.3–32) | 0 (0–4) | < 0.001 |
AF atrial fibrillation, CAD coronary artery disease, CHF congestive heart failure, CT computed tomography, ED emergency department, EMS emergency medical services, ICH intracerebral hemorrhage, INR international normalized ratio, IVH intraventricular hemorrhage, LOC loss of consciousness, PTT partial thromboplastin time, SBP systolic blood pressure, SD Standard deviation, TIA transient ischemic attack, y year
aData are represented as number (%) or median (interquartile range), unless otherwise specified