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. 2021 May 24;23(6):809–817. doi: 10.1007/s11307-021-01614-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3. — Real-time in vivo HNSCC analysis. Patient 7 with an in-transit metastasis detected after biopsy of a fluorescent spot in the surgical cavity (a–c). Patient 9 with a tumor in the mandible with a positive spot for fluorescence in the surgical cavity, which showed high-grade dysplasia without invasive carcinoma (d–f). Patient 10 with a tumor in the mandible with a clear fluorescent spot indicating a focal tumor-positive surgical margin as confirmed by histopathological assessment (g–i). Mean fluorescence intensity (MFI) of the fluorescent spot compared to the background for all three patients (j) and tumor-to-background ratios derived from the MFI data in all three patients (k).