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. 2021 May 24;23(6):809–817. doi: 10.1007/s11307-021-01614-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4. — Flowchart real-time clinical decision-making. Suggested flowchart for fluorescence-guided surgery and surgical decision-making using fluorescence with this tumor generic fluorescence imaging agent. An additional surgical resection can be made in different scenarios when fluorescent spots with a tumor-to-background ratio of > 1.5 are observed on either the surgical specimen or in the surgical cavity.