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In utero and early life profiles of microbiome and immune maturation in children who do or do not develop asthma. Distinct developmental trajectories are shown as a dashed (asthma) or continuous (no asthma) line. The red horizontal arrow highlights the delay in immune and microbiome maturation that emerges at birth, persists through early life, and shifts the developmental trajectory to the right in children who later develop asthma.
