TABLE 2.
Prediction of All‐Cause Mortality After the Addition of E‐Cadherin Measurements to Standard Diagnostic Tests of Cancer Cell Detachment From Colorectal Primary Tumors
| E‐Cadherin Variable Added to Standard Tests | ||||
|---|---|---|---|---|
| Continuous | Dichotomous E‐Cadherin Cut Point | |||
| 0.52 | 0.60 | 0.85 | ||
| C‐index, % (95% CI) | 66 (58 to 72) | 51 (41 to 59) | 54 (45 to 62) | 56 (48 to 63) |
| Reclassification metric | ||||
| No. (%) moved to higher risk category | 47 (25) | 11 (6) | 27 (14) | 41 (22) |
| No. (%) moved to lower risk category | 55 (29) | 93 (49) | 83 (44) | 70 (37) |
| Total No. (%) reclassified | 102 (54) | 104 (55) | 110 (59) | 111 (59) |
| Reclassification calibration statistic P value | .1 | .1 | .1 | .2 |
| Event net reclassification index, % (95% CI) | 14 (–11 to 30) | –22 (–38 to –7) | –7 (–23 to 10) | 3 (–15 to 21) |
| Nonevent net reclassification index, % (95% CI) | 13 (3 to 35) | 54 (44 to 63) | 41 (29 to 52) | 24 (12 to 37) |
| Integrated discrimination improvement, % (95% CI) | 3.4 (1.9 to 5.6) | 4.3 (2.2 to 6.8) | 3.4 (1.8 to 5.3) | 3.7 (1.7 to 5.9) |
Abbreviation: CI, confidence interval.
E‐cadherin was measured on a continuous average intensity scale of 0 to 3 and then modeled as either continuous or dichotomized at a given cut point. Each C‐index value is for a Cox model of all‐cause mortality based on standard diagnostic tests of cancer cell detachment (lymph node evaluation and radiologic imaging) plus the respective E‐cadherin variable. Reclassification metrics compare a Cox model of standard diagnostic tests estimating all‐cause mortality to a Cox model of standard diagnostic tests plus the respective E‐cadherin variable. This table was modified with permission from Table 4 in Busch et al. 30 , which was published under a CC BY 4.0 license.