Table 1.

PK/PD parameters of daptomycin against S. aureus ATCC 33,591 and S. epidermidis ATCC 29,887 at different multiples of the minimum inhibitory concentration (0.5 μg/mL)

Multiples MIC	0.25 × MIC	0.5 × MIC	1 × MIC	3 × MIC	5 × MIC	10 × MIC
Parameters							Average	SD
Staphylococcus aureus ATCC 33,591
k0 (h−1)	0.115	0.191	0.493	0.175	0.169	0.168	0.218	0.136
Nmax (CFU/mL)	8.605	8.521	8.147	8.407	8.436	8.437	8.425	0.154
kmax (h−1)	0.015	0.033	0.200	0.356	0.564	0.705	0.312	0.282
EC50 (μg/mL)	0.544	0.602	0.647	0.482	0.184	0.149	0.434	0.215
h (h−1)	0.120	0.107	0.234	0.068	0.014	0.007	⁄	⁄
x (h−1)	0.029	0.061	0.046	0.482	0.211	0.167	⁄	⁄
z (h−1)	1.810	1.296	1.877	1.044	1.040	1.228	⁄	⁄
Staphylococcus epidermidis ATCC 29,887
k0 (h−1)	0.452	0.443	0.394	0.487	0.438	0.445	0.443	0.029
Nmax (CFU/mL)	17.412	16.958	17.008	17.005	17.029	17.015	17.071	0.168
kmax (h−1)	0.121	0.496	0.531	0.712	0.701	0.622	0.530	0.218
EC50 (μg/mL)	0.343	0.766	0.871	0.405	0.314	0.326	0.504	0.247
h (h−1)	0.480	0.368	0.362	0.169	0.255	0.374	⁄	⁄
x (h−1)	0.106	0.130	0.153	0.114	0.130	0.129	⁄	⁄
z (h−1)	0.056	0.283	0.430	0.436	0.467	0.325	⁄	⁄