Table 1.
miR-21 expression pattern in cardiomyopathies.
| Disease | Animal study | Clinical study | Biomarker |
|---|---|---|---|
| MI | Rat Heart # (33) Mouse Heart* (34) Rat Heart↑ (31, 35) Mouse Heart↓ (36) |
Plasma* (37) Serum ↑ (38) |
✓ |
| CAD | Mouse Plasma↑(39) | Plasma↑ (6, 39–41) PBMCs↓ (42) |
✓ |
| AF | Rabbit Heart↑ (43) | Left atria↑(44) Myocytes↑ (45) Plasma↓ (46) Serum ↓ (47) |
✓ |
| HF | Plasma ↑ (48) Serum ↓ (49) Plasma* (50) |
✓ | |
| DCM | Mouse Heart ↑ (26, 51) Mouse Heart↓ (52) | Heart ↑ (53) Serum ↑ (54) |
✓ |
| I/R Injury | Mouse Heart ↑ (55, 56) Rat Heart ↓ (57) |
Heart ↑ (58) | ✓ |
Myocardial infraction (MI), Coronary artery disease (CAD), Atrial Fibrillation (AF), Heart Failure (HF), Diabetic cardiomyopathy (DCM), Ischemia-Reperfusion injury (I/R injury), Time-dependent change *, Site-dependent change #, Increase ↑, Decrease ↓, Suggested as a biomarker ✓.